2.5-point line separates 76ers and Pistons in Detroit

The Philadelphia 76ers and Detroit Pistons are separated by a 2.5-point betting spread as they face off in Detroit on Wednesday.

The two teams lead the Eastern Conference standings after four weeks of play. Philadelphia holds a 7-1 record, while Detroit is 6-1. The 76ers share the best record in the league with the Houston Rockets. Despite their winning percentage, Philadelphia ranks 10th in point differential at +5.8 points per game. Detroit leads the NBA in defensive efficiency, allowing 102 points per 100 possessions.

The Pistons have dominated this matchup in recent years. Detroit has won the last six meetings against Philadelphia. That streak began in February 2025. The most recent meeting occurred last month in Philadelphia, where Detroit won by 13 points. Neither Joel Embiid nor VJ Edgecombe played for the 76ers in that game. The Pistons also missed Jalen Duren and Ausar Thompson. Philadelphia has scored 110.6 points per 100 possessions this season, ranking 19th in the league.

The 76ers have relied on late-game performance for their success. Six of their seven wins came in games that were within five points in the final five minutes. Detroit held Philadelphia to their worst offensive output of the season on October 25. The Pistons won that matchup 106-93.

Another marquee NBA game takes place Wednesday night in San Antonio. The Dallas Mavericks travel to face the San Antonio Spurs. This will be the first in-season meeting between Cooper Flagg and Victor Wembanyama. The teams met on October 24, with the Spurs winning 122-106. Flagg missed that game due to a shoulder ailment. The Spurs have won five consecutive games since that victory. During that run, San Antonio has averaged 118.9 points per 100 possessions. Flagg has averaged 26.3 points, 7.8 assists, 6.0 rebounds, 2.3 steals, and 1.0 block in his last four games.

The college football slate includes three notable games in the Mid-American Conference. UMass hosts Ball State at 7 p.m. ET in Amherst, Massachusetts. The Minutemen are 4-4 overall and 1-3 in conference play. They have lost four straight games after winning their first four, including an upset of Rutgers. Ball State is 3-5 overall and 2-2 in the MAC. The Cardinals allow 35.3 points per game, ranking 131st in the nation. They also rank 115th in rushing defense, allowing 183.1 yards per game.

Toledo visits Sacramento State at 7 p.m. ET. The Rockets are 6-2 overall and 3-1 in conference play. They sit fourth in the MAC behind Ohio, Western Michigan, and Buffalo. Sacramento State is 2-7 overall and 1-5 in the MAC. The Hornets are coming off their first conference victory of the season. They defeated Kent State 31-10 on the previous weekend. Sacramento State forced five turnovers in that game. Toledo has turned the ball over six times in its last three contests.

Central Michigan plays Eastern Michigan at 7:30 p.m. ET at Ford Field in Detroit. The Eagles are 4-5 overall and 3-2 in conference play. The Chippewas are 3-5 overall and 1-3 in the MAC. Both teams have shown increased offensive production in league games. Eastern Michigan averages 25 points in MAC play compared to 16.8 in nonconference games. Central Michigan scores 24 points per game against conference opponents, up from 11.8 against non-league teams. The total points line for this game is set at 44.5.

All listed times are Eastern. The games will air on various networks, including ESPN, Fubo, ESPNU, CBSSN, and ESPN2.